Virulence factors of Aggregatibacter actinomycetemcomitans - A status update
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چکیده
منابع مشابه
Virulence Mechanisms of Leukotoxin from Aggregatibacter actinomycetemcomitans
Aggregatibacter actinomycetemcomitans is a gram-negative bacterium that is present in the oral cavity of a large proportion of the human population (Zambon et al., 1983; Henderson et al., 2010) The bacterium is acquired through transmission from infected individuals and thought to initially colonize oral mucosa as a facultative intracellular pathogen (Fine et al., 2006). When the bacteria trans...
متن کاملDifferential transcription of virulence genes in Aggregatibacter actinomycetemcomitans serotypes
BACKGROUND Aggregatibacter actinomycetemcomitans serotypes are clearly associated with periodontitis or health, which suggests distinct strategies for survival within the host. OBJECTIVE We investigated the transcription profile of virulence-associated genes in A. actinomycetemcomitans serotype b (JP2 and SUNY 465) strains associated with disease and serotype a (ATCC 29523) strain associated ...
متن کاملStructural characteristics of potential novel virulence factors, the host cytokine binding proteins of Aggregatibacter actinomycetemcomitans
Various gram-negative pathogens possess secreted or outer membrane proteins (OMPs) which interact with host cytokines. Of periodontal pathogens only Aggregatibacter actinomycetemcomitans (Aa) has been shown to sequester and uptake cytokines. We have identified two (OMPs) of Aa, bacterial interleukin receptor I (BilRI) and OM secretin channel (OMS), which interact with several cytokines, the int...
متن کاملA Comparison of Aggregatibacter actinomycetemcomitans (Aa) Virulence Traits in a Rat Model for Periodontal Disease
Our aim was to explore the effects of Cytolethal Distending toxin (Cdt) in a well established rat model of periodontal disease where leukotoxin (LtxA) was thought to have no known effect. In vitro studies, were used to assess CdtB activity using Aa Leukotoxin as a negative control. These studies showed that both CdtB and LtxA (unexpectedly) exerted significant effects on CD4(+) T cells. As a re...
متن کاملEmaA, a potential virulence determinant of Aggregatibacter actinomycetemcomitans in infective endocarditis.
The gram-negative fastidious human oropharyngeal Aggregatibacter actinomycetemcomitans is implicated in the etiology of infective endocarditis. EmaA, an oligomeric coiled-coil adhesin homologous to YadA of Yersinia enterocolitica, was hypothesized to mediate the interaction of A. actinomycetemcomitans with collagen. Collagen, the most abundant protein in human bodies and the main component of e...
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ژورنال
عنوان ژورنال: Journal of the International Clinical Dental Research Organization
سال: 2015
ISSN: 2231-0754
DOI: 10.4103/2231-0754.164390